Publications

Highlights

Current and past lab members are highlighted in bold

A Bioorthogonal Precision Tool for human N-acetylglucosaminyltransferase V
Journal of the American Chemical Society, 2024


Yu Liu, Ganka Bineva-Todd, Richard Meek, Laura Mazo, Beatriz Piniello, Olga Moroz, Nadima Begum, Andre Ohara, Chloe Roustan, Sara Tomita, Svend Kjaer, Karen Polizzi, Carme Rovira, Gideon Davies, Benjamin Schumann

Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoprotein
RSC Chemical Biology, 2024


Abdul Zafar, Sandhya Sridhar, Ganka Bineva-Todd, Anna Cioce, Nadia Abdulla, Vincent Chang, Stacy Malaker, David Hewings, Benjamin Schumann

Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells
bioRxiv, 2023


Zhen Li, Lucia Di Vagno, Aisling Ni Cheallaigh, Douglas Sammon, David C Briggs, Nara Chung, Vincent Chang, Keira E Mahoney, Anna Cioce, Lloyd D Murphy, Yen-Hsi Chen, Yoshiki Narimatsu, Rebecca L Miller, Lianne I Willems, Stacy A Malaker, Gavin J Miller, Erhard Hohenester, Benjamin Schumann

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern
ACS Central Science, 2023

Edgar Gonzalez-Rodriguez, Mia Zol-Hanlon, Ganka Bineva-Todd, Andrea Marchesi, Mark Skehel, Keira E. Mahoney, Chloë Roustan, Annabel Borg, Lucia Di Vagno, Svend Kjær, Antoni G. Wrobel, Donald J. Benton, Philipp Nawrath, Sabine L. Flitsch, Dhira Joshi, Andrés Manuel González-Ramírez, Katalin A. Wilkinson, Robert J. Wilkinson, Emma C. Wall, Ramón Hurtado-Guerrero, Stacy A. Malaker, and Benjamin Schumann

Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells
STAR Protocols, 2023

Beatriz Calle, Edgar Gonzalez-Rodriguez, Keira E. Mahoney, Anna Cioce, Ganka Bineva-Todd, Omur Y. Tastan, Chloe Roustan,  Helen Flynn, Stacy A. Malaker, and Benjamin Schumann

Cell-specific bioorthogonal tagging of glycoproteins
Nature communications, 2022

Anna Cioce, Beatriz Calle, Tatiana Rizou, Sarah C Lowery, Victoria L Bridgeman, Keira E Mahoney, Andrea Marchesi, Ganka Bineva-Todd, Helen Flynn, Zhen Li, Omur Y Tastan, Chloe Roustan, Pablo Soro-Barrio, Mahmoud-Reza Rafiee, Acely Garza-Garcia, Aristotelis Antonopoulos, Thomas M Wood, Tessa Keenan, Peter Both, Kun Huang, Fabio Parmeggian, Ambrosius P Snijders, Mark Skehel, Svend Kjær, Martin A Fascione, Carolyn R Bertozzi, Stuart M Haslam, Sabine L Flitsch, Stacy A Malaker, Ilaria Malanchi, Benjamin Schumann

Benefits of chemical sugar modifications introduced by click chemistry for glycoproteomic analyses
Journal of the American Society for Mass Spectrometry, 2021 

Beatriz Calle, Ganka Bineva-Todd, Andrea Marchesi, Helen Flynn, Mattia Ghirardello, Omur Y Tastan, Chloe Roustan, Junwon Choi, M Carmen Galan, Benjamin Schumann, Stacy A Malaker

Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase
ACS Chemical Biology 2021

Anna Cioce, Ganka Bineva-Todd, Anthony J Agbay, Junwon Choi, Thomas M Wood, Marjoke F Debets, William M Browne, Holly L Douglas, Chloe Roustan, Omur Y Tastan, Svend Kjaer, Jacob T Bush, Carolyn R Bertozzi, Benjamin Schumann

Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools  
Current Opinion in Chemical Biology, 2021

Anna Cioce, Stacy A Malaker, Benjamin Schumann

Open questions in chemical biology
Nature Communications Chemistry, 2020 

Mia Zol-Hanlon, Benjamin Schumann

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation
PNAS, 2020 

Marjoke F Debets, Omur Y Tastan, Simon P Wisnovsky, Stacy A Malaker, Nikolaos Angelis, Leonhard KR Moeckl, Junwon Choi, Helen Flynn, Lauren JS Wagner, Ganka Bineva-Todd, Aristotelis Antononopoulos, Anna Cioce, William M Browne, Zhen Li, David C Briggs, Holly L Douglas, Gaelen T Hess, Anthony J Agbay, Chloe Roustan, Svend Kjaer, Stuart M Haslam, Ambrosius P Snijders, Michael C Bassik, WE Moerner, Vivian SW Li, Carolyn R Bertozzi, Benjamin Schumann

Bump-and-hole engineering identifies specific substrates of glycosyltransferases in living cells
Molecular Cell, 2020

Benjamin Schumann, Stacy Alyse Malaker, Simon Peter Wisnovsky, Marjoke Froukje Debets, Anthony John Agbay, Daniel Fernandez, Lauren Jan Sarbo Wagner, Liang Lin, Zhen Li, Junwon Choi, Douglas Michael Fox, Jessie Peh, Melissa Anne Gray, Kayvon Pedram, Jennifer Jean Kohler, Milan Mrksich, Carolyn Ruth Bertozzi

Bump-and-hole engineering identifies specific substrates of glycosyltransferases in living cells
Molecular Cell, 2020

Benjamin Schumann, Stacy Alyse Malaker, Simon Peter Wisnovsky, Marjoke Froukje Debets, Anthony John Agbay, Daniel Fernandez, Lauren Jan Sarbo Wagner, Liang Lin, Zhen Li, Junwon Choi, Douglas Michael Fox, Jessie Peh, Melissa Anne Gray, Kayvon Pedram, Jennifer Jean Kohler, Milan Mrksich, Carolyn Ruth Bertozzi

All Publications

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis
Nature Communications, 2023

Douglas Sammon, Anja Krueger, Marta Busse-Wicher, , Rhodri Marc Morgan, Stuart M. Haslam, Benjamin Schumann, David C. Briggs, & Erhard Hohenester 

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth
Oncogene, 2023

Jennifer Munkley, Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L McClurg, Laura Wilson, Huw Thomas, Fiona M Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann DeBono, Norman Maitland, Simon Wisnovsky, Carolyn Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David Elliott, Benjamin Schumann

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates
ASM Infection and Immunity, 2023

Daniel A Pensinger, Andrea T Fisher, Horia A Dobrila, William Van Treuren, Jackson O Gardner, Steven K Higginbottom, Matthew M Carter, Benjamin Schumann, Carolyn R Bertozzi, Victoria Anikst, Cody Martin, Elizabeth V Robilotti, JoMay Chow, Rachael H Buck, Lucy S Tompkins, Justin L Sonnenburg, Andrew J Hryckowian

Celebrating the Contributions of Carolyn Bertozzi to Bioorthogonal Chemistry and its Application to Glycoscience
Israel Journal of Chemistry, 2023

Jessica R. Kramer, Matthew R. Pratt, Benjamin Schumann

4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase
ACS Chemical Biology, 2021

Emma G Jackson, Giuliano Cutolo, Bo Yang, Nageswari Yarravarapu, Mary WN Burns, Ganka Bineva-Todd, Chloë Roustan, James B Thoden, Halley M Lin-Jones, Toin H van Kuppevelt, Hazel M Holden, Benjamin Schumann, Jennifer J Kohler, Christina M Woo, Matthew R Pratt

Engineering orthogonal polypeptide GalNAc-transferase and UDP-sugar pairs
JACS, 2019

Junwon Choi, Lauren JS Wagner, Suzanne BPE Timmermans, Stacy A Malaker, Benjamin Schumann, Melissa A Gray, Marjoke F Debets, Megumi Takashima, Jase Gehring, Carolyn R Bertozzi

Improving vaccines against Streptococcus pneumoniae using synthetic glycans
PNAS, 2018

Paulina Kaplonek, Naeem Khan, Katrin Reppe, Benjamin Schumann, Madhu Emmadi, Marilda P Lisboa, Fei-Fei Xu, Adam DJ Calow, Sharavathi G Parameswarappa, Martin Witzenrath, Claney L Pereira, Peter H Seeberger

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1
ACS Central Science, 2018

Benjamin Schumann, Katrin Reppe, Paulina Kaplonek, Annette Wahlbrink, Chakkumkal Anish, Martin Witzenrath, Claney L Pereira, Peter H Seeberger


Total Synthesis of a Densely Functionalized Plesiomonas shigelloides Serotype 51 Aminoglycoside Trisaccharide Antigen
JACS, 2018

Chunjun Qin, Benjamin Schumann, Xiaopeng Zou, Claney L Pereira, Guangzong Tian, Jing Hu, Peter H Seeberger, Jian Yin

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine
Science Translational Medicine, 2017

Benjamin Schumann, Heung Sik Hahm, Sharavathi G Parameswarappa, Katrin Reppe, Annette Wahlbrink, Subramanian Govindan, Paulina Kaplonek, Liise-anne Pirofski, Martin Witzenrath, Chakkumkal Anish, Claney L Pereira, Peter H Seeberger

Nucleophile-Directed Stereocontrol Over Glycosylations Using Geminal-Difluorinated Nucleophiles
Angewandte Chemie International Edition, 2016

Benjamin Schumann, Sharavathi G Parameswarappa, Marilda P Lisboa, Naresh Kottari, Fabio Guidetti, Claney L Pereira, Peter H Seeberger

Chemical biology approaches to designing defined carbohydrate vaccines
Cell Chemistry & Biology, 2014

Chakkumkal Anish, Benjamin Schumann, Claney Lebev Pereira, Peter H Seeberger

Synthesis of conjugation-ready zwitterionic oligosaccharides by chemoselective thioglycoside activation
RSC Chemical Science, 2014

Benjamin Schumann, R Pragani, Chakkumkal Anish, Claney Lebev Pereira, Peter H Seeberger

Benjamin Schumann, Chakkumkal Anish, Claney L Pereira, Peter H Seeberger

A crucial role for Mim2 in the biogenesis of mitochondrial outer membrane proteins
Journal of Cell Science, 2012

Kai S Dimmer, Dražen Papić, Benjamin Schumann, Desirée Sperl, Katrin Krumpe, Dirk M Walther, Doron Rapaport​